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Quantitative Trait Loci Analysis in Animals, 2nd Edition
By J Weller, Agricultural Research Organisation, Israel
Main Description
Quantitative Trait Loci (QTL) is a topic of major agricultural significance for efficient livestock production. This advanced-level textbook covers all the statistical methods that have been used or proposed for detection and analysis of QTL and marker- and gene- assisted selection in animal genetics and breeding, as well as new advances that have revolutionized the field since the first edition.
Readership
Graduate students and researchers in genetics/genetic markers/quantitative genetics, applied animal breeding, bioinformatics.
Main Contents
1. Principles of Parameter Estimation 2. Random and Fixed Effects, the Mixed Model 3. Historical Overview 4. Experimental Designs to Detect QTL, Generation of Linkage Disequilibrium 5. QTL Parameter Estimation for Crosses between Inbred Lines 6. Advanced Statistical Methods for QTL Detection and Parameter Estimation 7. Analysis of QTL as Random Effects 8. Statistical Power to Detect QTL, and Parameter Confidence Intervals 9. Optimization of Experimental Designs 10. Fine Mapping of QTL 11. Complete Genome QTL Scans: The Problem of Multiple Comparisons 12. Multiple Trait QTL Analysis 13. Principles of Selection Index and Traditional Breeding Programmes 14. Marker-assisted Selection:Theory 15. Marker-assisted Selection : Results of Simulation Studies 16. Marker-assisted Introgression
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