Main Description

Parasitic flatworms include Cestodes (tapeworms) and trematodes (flukes, schistosomes, etc) and are the cause of a number of major diseases of medical and veterinary significance. Much recent research has focused on molecular biology and genomics. this book aims to review advances in our understanding of these and related topics such as flatworm biochemistry, immunology and physiology. Where appropriate, comparisons are made between different parasitic flatworms and between parasitic and free-living species. Contributors to the book include leading authorities from Europe, North and South America, and Australia.

Readership

Researchers in parasitology, immunology and infectious diseases.

Main Contents

Part I: Phylogeny, Genetics and Transcriptomes



The Evolution of Parasitism in Flatworms, D T J Littlewood, Natural History Museum, UK

Genomes and Genomics of Parasitic Flatworms, D A Johnston, Natural History Museum, UK

Genetic Discrimination of Echinococcus Species and Strains, D P McManus, University of Queensland, Australia

Ribosomal DNA Variation in Parasitic Flatworms, D Blair, James Cook University, Australia

Genetic Studies on Monogeneas with Emphasis on Gyrodactylus, ,CO Cunningham and I Matějusová, FRS MarineLaboratory, Aberdeen, UK

The Schistosome Transcriptome, S Verjovski-Almeida and R DeMarco, Universidade de Sao Paulo, Brazil

Transgenic Flatworms, C G Grevelding, Justus-Liebig-University Giessen, Germany

Part II: Immunobiology, Host-Parasite Interaction and Control



Immunobiology of Schistosomes, S G Forrester, University of Ontario, Canada and E J Pearce, University of Pennsylvania, USA

Cestode Infection: Immunological Considerations From Host and Tapeworm Perspectives, D M McKay, McMaster University, and R A Webb, York University, Canada

Parasitic Flatworms: Signal Transduction at the Host-Parasite Interface, T P Yoshino, J J Vermeire and J Humphries, University of Wisconsin-Madison, USA

Parasite Effects on the Snail Host Transcriptome, M Knight and N Raghavan, Biomedical Research Institute, USA

Developments in the chemotherapy of parasitic flatworms, G C Coles, University of Bristol, UK

Drug Resistance in Schistosomes, T A Day, Iowa State University, USA and S Botros, Theodor Bilharz Research Institute, Egypt

Praziquantel: Mechanism of Action, R M Greenberg, Marine Biological Laboratory, Woods Hole, MA, USA

Cestode Vaccine Development, M W Lightowlers, University of Melbourne, Australia

The Development of a Schistosome Vaccine, R A Wilson and P S Coulson, University of York, UK

Part III: Protein Function, Metabolism and Physiology



Flatworm Parasite Proteomics, R M Morphew, J Barrett and P M Brophy, University of Wales, UK

Proteases in Trematode Biology, J P Dalton, University of Technology, Australia, C R Caffrey, M Sajid, University of California, USA, C Stack, S Donnelly, University of Technology, Australia, A Loukas, T Don, Queensland Institute of Medical Research, J McKerrow, University of California, USA, D W Halton, Queen’s University Belfast, UK and P J Brindley, Tulane University Health Sciences Center, USA

Signalling Molecules and Nerve-Muscle Function, A G Maule, N J Marks and T A Day

Unusual Aspects of Metabolism in Flatworm Parasites, A G M Tielens and J J van Hellemond, Utrecht University, Netherlands

Glycoconjugate Structures, M Wuhrer, Leiden University Medical Center, Netherlands and R Geyer, University of Giessen, Germany

Gene Silencing in Flatworms using RNA interference, P J Skelly, TuftsUniversity School of Veterinary Medicine, USA

Parasitic flatworms include Cestodes (tapeworms) and trematodes (flukes, schistosomes, etc) and are the cause of a number of major diseases of medical and veterinary significance. Much recent research has focused on molecular biology and genomics. this book aims to review advances in our understanding of these and related topics such as...