Peptides in Energy Balance and ObesityFrontiers in Nutritional Science
By G Frühbeck, Clinical Scientist - Head of the Metabolic Research Laboratory, University of Navarra, Spain
Obesity is one of the most relevant public health concerns today and it is now evident that body weight control is achieved through highly integrated physiological interactions like nutrient selection as well as being influenced by genetic and environmental factors. Moreover, energy balance regulation is a complex process aimed at maintaining constant energy stores. Presenting a detailed and comprehensive account of the roles of specific peptides in energy balance, food intake control and co-morbidities, this review provides a better understanding of the patho-physiology of energy balance and obesity.
Researchers and students in nutrition science and medical nutrition.
Section 1: Central pathways involved in the control of food intake and energy expenditure 1. Orexigenic neuropeptides: Hypothalamic regulation of appetite2. Anorexigenic peptides3. Newcomers and supporting actorsSection 2: Peripheral signals participating in energy homeostasis and obesity: associated alterations 4. The gut as a second brain5. The adipo-hepato-insular axis in glucose homeostasis6. Elements of the adipostat7. Adipocytokines participating in the immune-stress response8. Peptides involved in vascular homeostasis9. Natriuretic peptides and other lipolytic peptides involved in the control of lipid mobilizationSection 3: Integrative Perspectives 10. Hierarchy of neural pathways controlling energy homeostasis11. Relevance of reward signals in the homeostatic control of energy balance12. Overview of the Integrative physiology of adipose tissue in energy homeostasis13. Is the energy homeostasis system inherently biased toward weight gain? A teleological molecular physiological and clinical view14. Embracing complexity: The emergence of functional neuroimaging and other methodologies to study the role of the human brain in the pathophysiology of obesity.15. Application of "OMICS" strategies to obesity research16. Implications for the future of obesity management
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