Quantitative Trait Loci (QTL) is a topic of major agricultural significance for efficient livestock production. This advanced-level textbook covers all the statistical methods that have been used or proposed for detection and analysis of QTL and marker- and gene- assisted selection in animal genetics and breeding, as well as new advances that have revolutionized the field since the first edition.
Graduate students and researchers in genetics/genetic markers/quantitative genetics, applied animal breeding, bioinformatics.
1. Principles of Parameter Estimation
2. Random and Fixed Effects, the Mixed Model
3. Historical Overview
4. Experimental Designs to Detect QTL, Generation of Linkage Disequilibrium
5. QTL Parameter Estimation for Crosses between Inbred Lines
6. Advanced Statistical Methods for QTL Detection and Parameter Estimation
7. Analysis of QTL as Random Effects
8. Statistical Power to Detect QTL, and Parameter Confidence Intervals
9. Optimization of Experimental Designs
10. Fine Mapping of QTL
11. Complete Genome QTL Scans: The Problem of Multiple Comparisons
12. Multiple Trait QTL Analysis
13. Principles of Selection Index and Traditional Breeding Programmes
14. Marker-assisted Selection:Theory
15. Marker-assisted Selection : Results of Simulation Studies
16. Marker-assisted Introgression